Changes of mitogen-activated protein kinases signal transduction pathway in ischemia/reperfusion injury
- VernacularTitle:缺血/再灌注损伤时丝裂原活化蛋白激酶信号转导通路的变化
- Author:
Qi CAI
;
Xiaomei LI
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Ischemia;
Reperfusion injury;
Mitogens protein kinase
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), c-Jun NH2-terminal kinases (JNKs) and p38 MAPK, play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus in mammalian cells by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. It was recently found that the changes in activity of MAPKs occurred during ischemia/reperfusion, but the biological significance of the changes was still controversial.
