Efficacy of general anesthesia combined with thoracic epidural anesthesia on the stress to experimental myocardial infarction in rabbits
- VernacularTitle:全麻复合胸段硬膜外阻滞对兔实验性心肌梗死应激反应的影响
- Author:
Zhiyang CHEN
;
Zhanggang XUE
;
Hao JIANG
- Publication Type:Journal Article
- Keywords:
Anesthesia,general;
Anesthesia, epidural;
Myocardial infarction;
Stress
- From:
Chinese Journal of Anesthesiology
1997;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the stress to experimental myocardial infarction under general anesthesia combined with thoracic epidural anesthesia(TEA) Methods Nine rabbits in experimental group were anesthetized with 1% sodium pentobarbitone with tracheal intubation after sectioned, and after the epidural catheters was put into to make sure that the epidural anesthesia was effective, the anterior descending branches of their left coronary artery were ligated All procedures in control group were similar to those of experimental group except for thoracic epidural anesthesia The blood samples from left common carotid artery before ligation were taken 15,30,60,120,180 and 240min after ligation, to measure the plasma levels of monoamine neurotransmitters with high performence liquid chromatography, the Ag Ⅱ and cortisol levels with radioimmunoassay TNFa content in non infarction myocardium was assessed with immunohistochemistry Results There were no differences in NE and 5 HT levels between both groups before ligation Thirty min after the ligation, NE level in experimental group remained unchanged, but in control group increased markedly(P
