Action of Triptolide in the Expressions of IL-5,GM-CSF mRNA in Pulmonary Tissue of Asthmatic Guinea Pig
- VernacularTitle:雷公藤甲素对哮喘豚鼠肺组织表达IL-5、GM-CSFmRNA的作用
- Author:
Xiaoming GUO
;
Aiyun GUO
;
Lirong FAN
- Publication Type:Journal Article
- Keywords:
Asthma,Animal model;
Triptolide;
Interleukin-5;
Granulocyte-Macrophage;
Colony stimulating factor
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
To research the expressions of IL-5,granulocyte macrophage colony stimulating factor(GM-CSF) in the asthmatic guinea pig pulmonary tissue and influence of triptolide on the expression,30 guinea pigs were divided at random into three groups:the asthma group(n=10),treated group(n=10) and control group(n=10).The expression levels of the IL-5,GM-CSF mRNA were detected by using in situ hybridization method.The results showed that the expressive intensities of IL-5,GM-CSF mRNA in asthma group were 36 38?7 65 and 32 78?9 43 respectively;the treated group were 17 46?7 32 and 18 92?6 38 respectively;control group were 13 82?5 43 and 18 27?7 45 respectively.The expressive intensities of IL-5,GM-CFS mRNA in asthmatic group were obviously higther than those of both treated and control groups,there was significantly difference between two groups(P
