Study of Manufacturing Technology for Acetaminophen Extended Release Tablets
- VernacularTitle:对乙酰氨基酚缓释片的生产工艺研究
- Author:
Wen SHI
;
Xinxia WANG
- Publication Type:Journal Article
- Keywords:
acetaminophen extended release tablets;
dissolution;
bioavailability;
technology of preparation
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To achieve an optimum manufacturing process for acetaminophen extended release tablets. METHODS: To evaluate and set the manufacturing process according to the compressibility of the granule and the dissolubility of the finished tablets. RESULTS & CONCLUSION: The results showed that the bi-layer tablet technology was the most preferable pro- cess. The in vitro dissolution behavior and the in vivo bioavailability of the tablets are comparable to those of the imported products from McNEIL Consumer Healtheare Co. USA.
