The Effect of INO Therapy on NOS in Piglet Suffered from Meconium Aspiration Syndrome
- VernacularTitle:吸入一氧化氮对胎粪吸入综合征新生猪一氧化氮合酶的影响
- Author:
Ziyu HUA
;
Danhua WANG
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Meconium aspiration;
Geneexpression;
Nitric oxide synth
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of inhaled nitric oxide(INO) on the nitric oxide synthase (NOS) in piglet suffered from severe meconium aspiration syndrome(MAS). Methods Severe MAS model of piglet was reproduced, the oxygenation effect and the activity of pulmonary NOS were measured, hybridization in situ of pulmonary slices was used to show the gene expression of inducible NOS(iNOS). Results INO therapy attenuated respiratory dysfunction in MAS, while discontinuation of INO induced “rebound pulmonary hypertension”. The activity of iNOS in MAS group is higher than that in control group (16.9?3.1) fmol/(mg Pro?min)vs (11.6?2.7) fmol/(mg Pro?min),( P
