A Study of Cocaine Induced Hepatic Damage in Newborn Rabbits
- VernacularTitle:可卡因对新生兔肝脏损害的研究
- Author:
Zhongxiong LIU
;
Chengzhi FANG
;
Yi JIANG
- Publication Type:Journal Article
- Keywords:
Cocaine;
Liver diseases;
Rabb
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the effects of chronic prenatal exposure to cocaine on hepar in the newborn rabbit at birth. Methods The pregnant Japan long ear white rabbits were divided randomly into cocaine group( N =12) and normal control( N =12). Pregnant rabbits were treated with cocaine hydrochloride 5 mg/kg or normal saline 1 ml/kg intravenously, one time daily from day 15 of pregnancy until day 30 respectively. Serum aspartate aminotransferase(AST), albumin(ALB), total bilirubin(T BIL), hepatic glutathione(GSH) were examined. Results (1)The levels of serum AST, T-BIL were significantly higher in the cocaine group than that in the control group( P
