Effect of exogenous carbon monoxide on the hypoxic pulmonary arterial hypertension in the rat
- VernacularTitle:一氧化碳对低氧性肺动脉高压的效应
- Author:
Guansong WANG
;
Chunji HUANG
;
Guisheng QIAN
;
Zhiqiang ZHAO
;
Wei YAO
;
Weizhong CHEN
- Publication Type:Journal Article
- Keywords:
Anoxia;
Hypertension, pulmonary;
Carbon monoxide;
Hemin;
Heme oxygenase
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of exogenous carbon monoxide (CO) on the hypoxic pulmonary arterial hypertension in the rat. METHODS: 60 rats were randomly divided into 5 groups: Normal group\, hypoxic group\, Hermin group\, Znpp group and CO group. HO-1 activity was examined by spectrophotometer and lung tissues was stained by immunohistochemical method. HO-1 mRNA level was tested by reverse transcriptase polymerase chain reaction (RT-PCR). RESULTS: (1) The pulmonary arterial pressure (18.52?3.24 mmHg) in CO group was higher than anoxic group and lower than hypoxic group (P
