Effect of lidocaine on voltage-dependent sodium current in dissociated hippocampal neurons of the rat
- VernacularTitle:利多卡因对大鼠海马锥体神经元电压依赖性钠通道的作用
- Author:
Weizhen WANG
;
Xinmin WU
- Publication Type:Journal Article
- Keywords:
Lidocaine;
Patch-clamp techniques;
Hippocampas;
Neuron;
Sodium channels
- From:
Chinese Journal of Anesthesiology
1995;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of variant concentrations of lidocaine on voltage-dependent sodium current in dissociated hippocampal neurons of the ratMethods Voltage-dependent sodium currents in dissociated hippocampal neurons of the rat were recorded by whole-cell configuration of the patch clamp when a series of doses of lidocaine (10 -5mol/L-10 -2mol/L) were appliedResults Lidocaine reduced the amplitude of sodium current in a dose-dependent manner, with EC50 of (039?005)mmol/LConclusions Voltage-dependent sodium channel is related to cerebral protective effect of lidocaine, but has nothing to do with its nervous toxicity
