Effect of mininally modified low density lipoprotein on the adhesive function of vascular endothelial cell and its mechanism
- VernacularTitle:轻度修饰低密度脂蛋白对血管内皮细胞粘附功能影响及其机理初探
- Author:
Chunhua LIU
;
Guanqing QIAN
;
Huiqi LIU
;
Xiaohui LIU
- Publication Type:Journal Article
- Keywords:
Endothelium;
Cells;
Lipoproteins, LDL;
Adhesions
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of MM-LDL (minimally modified LDL) on the interaction between human umbilical vein endothelial cell (HUVEC) and U937 monocyte-like cell line and the exporession of vascular cell adhesion-1 (VCAM-1), intercellular adhesion molecule-1(ICAM-1), P-selectin.METHODS:The adhesive percentage between HUVEC treated with MM-LDL and U937 was determined by counting and the expression of VCAM-1, ICAM-1, P-selectin were examined by ELISA. RESULTS: Treatment of HUVEC with MM-LDL (75 mg/L) for 4 hours significantly increased adhesion of U937 to HUVEC ( P
