Role of oxidized LDL receptor in endothelial cellular injury by oxidized low-density lipoprotein
- VernacularTitle:氧化低密度脂蛋白内皮受体在氧化低密度脂蛋白致内皮细胞损伤中的作用
- Publication Type:Journal Article
- Keywords: Receptors, LDL; Endothelium; Cells; Alteplase; Inhibin
- From: Chinese Journal of Pathophysiology 2000;0(10):-
- CountryChina
- Language:Chinese
- Abstract: AIM: To explore the role of LOX1 in endothelial cellullar injury by ox-LDL. METHODS: The morphological changes of endothelial cells were observed with inverted phasecontrast microscope; tissue plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1)activity were measured with chromogenix;LOX1 mRNA expression was detected by reverse transcription-polymerase chain reaction(RT-PCR). RESULTS: Incubation of ox-LDL induced endothelial cells contraction and cellular membrane rupture, increased LOX1 mRNA expression,PAI-1 activity 3 times than control per 24 h per 10 5( P