Changes in endothelin-1 and atrial natriuretic factor and the effect of atrial natriuretic factor on the change of endothelin-1 in asthmatic guinea pigs
- VernacularTitle:哮喘豚鼠内皮素、心钠素含量的变化及心钠素对内皮素含量的影响
- Author:
Shanlin DAI
;
Mao HUANG
;
Hong WANG
;
Kaisheng YING
- Publication Type:Journal Article
- Keywords:
Asthma;
Endothelins;
Atrial natriuretic factor;
Guanosine cyclic monophosphate
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the possible role of endothelin(ET-1) in asthma pathogenesis and the effect of atrial natriuretic factor (ANF) on changes of ET-1. METHODS: Measuring the contents of endothelin-1(ET-1),atrial natriuretic factor(ANF),cGMP in plasma and bronchoalveolar lavage fluid (BALF) of guinea pigs. RESULTS: The contents of ET-1, ANF and cGMP in asthma group were higher than that of the control group; There was a significant negative correlation between ET-1 and ANF( r=-0.638,P
