Effects of desflurane on Ca~(2+)-ATPase activity of plasma membrane of rat cardicc myocyte
- VernacularTitle:地氟醚对大鼠心肌细胞质膜钙ATP酶活性的影响
- Author:
Ying ZHANG
;
Xinliang ZHUANG
;
Guohui XU
- Publication Type:Journal Article
- Keywords:
Desflurane;
Myocardium;
Ca 2+-Transporting ATPase
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of desflurane on Ca 2+-ATPase activity isolated rat cardiac myocyte plasma membrane ,for the mechanisms of its inhibitory myocardial function.Methods The effects of different concentration desflurane(0%-11%) on Ca 2+-ATPase activity were studied at different calcium concentration(04-20?mol/L) and at 25℃ or 37℃Results Ca 2+-ATPase activity wan depressed by desflurane,the greater inhibitory effect,the higher desflurane concentration,and more severely at low calcium concentration or at 37℃ than at high calcium concentration or at 25℃Conclusions At clinical concentration desflurane produces tha inhibitory effect on rat cardiac myocyte plasma membrane Ca 2+-ATPase activity dose-dependently,which may in part explain its depression on myocardial function.
