Effects of smecta in prolonged hemorrhagic shock
- VernacularTitle:思密达在重度失血性休克中的应用
- Author:
Huadong ZHU
;
Chunhua YU
;
Yushu ZHOU
- Publication Type:Journal Article
- Keywords:
Shock,hemorrhagic;
Endotoxin;
Tumor necrosis factor;
Interleukin-6;
Nitric oxide;
Smecta
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of smecta in prolonged hemorrhagic shock.Methods The modified Wigger's method was used to induce hemorrhagic shock in anesthetized rabbits.Twenty-nine rabbits were randomly divided into hemorrhagic shock group(n=14),smecta group(n=15),with smecta solution being administered via a gavage tube before shock.The plasma levels of endotoxin,tumor necrosis factor ?(TNF?),interleukin-6(IL-6) and nitric oxide(NO) were detected at pre-shock and post-shock,immediately after resuscitation and 2h after resuscitation.Blood culture was done at pre-shock,immediately after resuscitation,2h after resuscitation.The survival rates of 24h and 48h were observed.Results The plasma levels of endotoxin,TNF?,IL-6 and NO markedly increased after shock,and were maintained at high level in shock group (P
