Role of intercellular adhesion molecule-1 in the lung inury induced by mechanical ventilation
- VernacularTitle:细胞间粘附分子-1在机械通气致肺损伤中的作用
- Author:
Xuejun CHEN
;
Liang WEN
;
Changlin YIN
- Publication Type:Journal Article
- Keywords:
Pulmonary ventilation;
Intercellular adhesion molecule-1;
Lung;
Wounds and injuries
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible role of intercellular adhesion molecule-1 (ICAM-1) in the lung injury induced by mechanical ventilationMethods Twenty-four normal healthy small pigs, ventilated with continuous different tidal volume, were randomly divided into control group, low tidal volume group (group A), middle tidal volume group (group B) and high tidal volume group (group C)The expression of ICAM-1 protein on pulmonary vascular endothelium cells, tumor necrosis factror-? (TNF-?) levels and myloperoxidase (MPO) activities in serum and lung were observed with immunohistochemisty, enzyme linked immunosorbent assay and MPO measurement 1d,3d and 7d following ventilation respectivelyResults The levels of TNF-? and MPO in serum and lung and the number of ICAM-1 protein expression were higher in group A, B and C than those in control group (P
