Protective effects of midazolam and propofol on myocardial ischemic reperfusion injury in patients undergoing open heart surgery
- VernacularTitle:咪唑安定及异丙酚对心内直视手术患者心肌缺血/再灌注损伤的保护作用
- Author:
Yetian CHANG
;
Liu LIU
;
Jianmei ZHOU
- Publication Type:Journal Article
- Keywords:
Midazolam;
Propofol;
Myocardial reperfusion injury;
Heart surgery
- From:
Chinese Journal of Anesthesiology
1996;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the protective effects of midazolam and propofol at equivalent dose on myocardial ischemia reperfusion injury during open heart surgery Methods Thirty six patients,scheduled for elective open heart surgery, were divided into midazolam (M), propofol (P) and no occluding (N) groups Before induction, a bolus of midazolam 0 2mg?kg -1 was given in group M or N , and a bolus of propofol 2 0mg?kg -1 in group P; after induction, midazolam was infused at 0 4mg?kg -1 ?h -1 in group M or N , and propofol at 4 0mg?kg -1 ?h -1 in group P The arterial blood samples were taken to measured the activities of serum enzymes ,at the beginning of CPB, 30min, 4, 12 and 24h after release of the aortic cross clamp Results As compared with those at at the beginning of CPB, the activities of serum enzymes increased significantly in three groups following declamping (P
