Homocysteine induces metallothionein formation in mice
- VernacularTitle:高同型半胱氨酸血症对小鼠金属硫蛋白合成的影响
- Author:
Shulian LI
;
Zaiquan LI
;
Ying ZHANG
;
Lin XUE
;
Song XU
;
Xiaohong WANG
;
Chaosh TANG
- Publication Type:Journal Article
- Keywords:
Homocysteine;
Metallothionein;
Stress
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the changes of metallothionein (MT) in various tissues of mice during hyperhomocysteinemia. METHODS: Intraperitoneal injection of homocysteine into mice induced hyperhomocysteinemia. The contents of tissue MT and malondialdehyde (MDA) in liver, heart and kidney were determined. RESULTS: Compared with control group, tissue MT levels in Hcy-group animals were increased by 210% ( P 0.05),respectively, compared with Hcy alone group. Tissue MDA contents were decreased by 24% ( P
