The effect of glucose, lactate and pyruvate on the dynamic adaptation of cardiac mitochondrial oxygen consumption
- VernacularTitle:葡萄糖、乳酸和丙酮酸对心肌线粒体氧耗动态适应的影响
- Author:
Xinqiang TIAN
- Publication Type:Journal Article
- Keywords:
Myocardium;
Mitochondria;
Oxidative phosphorylation;
Glucose;
Lactates;
Pyruvates
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To understand the effect of exogenous carbon substrate on the dynamic regulation of cardiac oxidative phosphorylation. METHODS: Method of mean response time measurement of the myocardial mitochondrial O 2 consumption (t mito ) was developed by van Beek. Glucose, lactate, or pyruvate as carbon substrate respectively for myocardial energy supply was perfused in isolated rabbit hearts with Tyrode solution at 37℃. RESULTS: When heart rate was stepped up from 120 to 140 and 220 (beat?min -1 ) respectively the t mito . We have measured was: (6.3?1.0) s and (7 4?0.9) s for glucose; (5.4?1.2) s and (7.0?0.9) s for lactate; (4.0?0.7)s and (6 5?0 6) s for pyruvate (two way ANOVA, P
