Changes of the contraction and relaxation of thoracic aortae in rats with chronic sinoaortic denervation
- VernacularTitle:长期去窦弓神经大鼠胸主动脉收缩和舒张功能的改变
- Author:
Xia TAO
;
Chaoyu MIAO
;
Zhengxu CHU
;
Dingfeng SU
- Publication Type:Journal Article
- Keywords:
Arteries;
Vasoconstriction;
Vasodilation
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate long-term effects of sinoaortic denervation (SAD) on the contraction and relaxation of thoracic aortae in rats.METHODS:SD rats underwent either SAD or sham operation at the age of 10 weeks. At 4,8, 16, and 32 weeks after operation, the contraction and relaxation of the thoracic aortae were measured by isolated artery technique.RESULTS:The NE-induced contraction and ACh-induced relaxation of aortic rings were progressively increased and depressed respectively after SAD.CONCLUSION:Vascular functional changes induced by purely blood pressure variability is similar to those observed in well-established experimental hypertensive states.
