Effects of angiotensin II receptor antagonist on remodeling of renal arterioles in hypertension
- VernacularTitle:血管紧张素Ⅱ受体拮抗剂对高血压肾小动脉重建的影响
- Author:
Xiangqun YANG
;
Jianliang ZHANG
;
Kaihong JI
;
Zonglai JIANG
;
Eryu CHEN
- Publication Type:Journal Article
- Keywords:
Angiotensin II/antagonists & inhibitors;
Receptors, angiotensin;
Renal artery;
Hypertension
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of angiotensin II receptor antagonist on remodeling of renal arterioles in hypertension. METHODS: Eighteen 4 weeks old male rats were divided into three groups: Wistar-Kyoto rats (WKY) for normotensive group, and spontaneously hypertensive rats (SHR) for hypertensive group, and SHR treated with losartan orally (15 mg?kg -1 ?d -1 ). The rats were raised to 16 weeks old. The morphometric parameters of the renal arterioles, and the widths of vascular smooth muscle cells (VSMC) and intercellular space were studied on kidney slices by light microscope and electromicroscope respectively, combined with computer-assistant image analysis system. The minimal renal vascular resistance (RVR min ) was studied by isolated kidney perfusion system. RESULTS: The systolic blood pressure of the tail artery, wall thickness, wall area, ratio of wall thickness to inner diameter, width of VSMC of renal arterioles and RVR min were all smaller or lower in losartan group than those of SHR. CONCLUSION: Ang II receptor antagonist losartan can prevent the remodeling of renal arterioles in SHR.
