Adhesion of bone marrow stromal cell in children with acute lymphoblastic leukemia
- VernacularTitle:急性淋巴细胞白血病患儿骨髓基质细胞的粘附行为
- Author:
Yun HUANG
;
Shunong LI
;
Xiaoyu LI
;
Suizhen LIN
;
Xuequn LUO
;
Zhaoyua QIN
- Publication Type:Journal Article
- Keywords:
Leukemia, lymphoblastic, acute;
Cell adhesion;
Cell adhesion molecules
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHOD: The adhesion behavior of bone marrow stromal cells(BMSC) in children with acute lymphoblastic leukemia(ALL) to bone marrow mononuclear cells(BMMC) and Raji cells were investigated by MTT method. The expression of adhesion molecules ICAM-1 and VCAM-1 were detected by flow cytometry. RESULTS: The adhesion ability of BMSC in acute period of ALL to BMMC was lower than that of control group. The adhesion ability of BMSC in long term remission period of ALL to Raji cells higher than that of control group. The expression of ICAM-1 on the surface of BMSC in acute period of ALL is much lower than that of control group. CONCLUSIONS: The adhesion of BMSC to BMMC or tumor cells in children with ALL was abnormal. The abnormal adhesion behavior might be partially due to the changed expression of adhesion molecules on BMSC.
