The alteration of extracellular sodium and potassium ionic activities of hippocampal neurons in epileptiform rats kindled by coriaria lactone
- VernacularTitle:马桑内酯致痫大鼠海马神经细胞外Na~+、K~+活度的变化
- Author:
Fei ZOU
;
Hong XIE
;
Shiming ZHONG
;
Na GAO
;
Ajing WANG
;
Changgen ZHU
- Publication Type:Journal Article
- Keywords:
Hippocampus;
Epilepsy;
Potassium;
Sodium;
Microelectrodes
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: The sodium ion(Na +) and potassium ion(K +) selective microelectrodes were used to measure changes of ionic activity of extracellular sodium and potassium([Na +] o, [K +] o) in hippocampus and hippocampal slice during epieptic seizure induced by intrahippocampal microinjection of coriaria lactone(CL) in rats and perfusing hippocampal slice with CL. RESULTS:30 s, 1min and 2min after injection of CL into hippocampus, the [Na +] o decreased 27.7 mmol/L, 50.3 mmol/L, 57.8 mmol/L respectively and the [K +] o increased 2.3 mmol/L, 2.4 mmol/L, 2.9 mmol/L respectively compared with control values( P
