The effect of partial liquid ventilation on the ultrastructure of pulmonary surfactant system in endotoxin-induced acute lung injury in rats
- VernacularTitle:部分液体通气对内毒素肺损伤肺表面活性物质系统超微结构的影响
- Author:
Xiaoming DENG
;
Jinbao LI
;
Keming ZHU
- Publication Type:Journal Article
- Keywords:
Pulmonary surfactants;
Lung injuries;
Ultrastructure
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of partial liquid ventilation on the ultrastructure of pulmonary surfactant(PS) system in endotoxin-induced acute lung injury METHODS: The effect of partial liquid ventilation on the ultrastructure of PS system in endotoxin-induced acute lung injury was observed with electronmicroscope histochemistry. RESULTS: There was ultrastructure impairment of PS system in endotoxin-induced acute lung injury, the pulmonary surfactant layer was discontinuous, lamellar bodies and plasmosomes in type Ⅱ pneumonocytes vacuolated, and a few of them were even necrotized and disrupted into the alveolar space. The pulmonary surfactant layer was still continuous, the vacuolation of lamellar bodies and plasmosomes in type Ⅱ pneumonocytes was little with partial liquid ventilation. CONCLUSION: Partial liquid ventilation can lessen the impairment of PS system in endotoxin-induced acute lung injury in rats.
