Relationship between apolipoprotein E gene polymorphism and sporadic Alzheimer's disease
- VernacularTitle:载脂蛋白E基因多态性与散发性老年性痴呆病的关系
- Author:
Tianpen CUI
;
Xin ZHOU
;
Hong XU
;
Fang ZHENG
- Publication Type:Journal Article
- Keywords:
Apolipoprotein E;
Alzheimer's disease;
Genes;
Enhancer elements
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the association between apolipoprotein E(apoE) gene polymorphism and sporadic Alzheimer's disease (AD). METHOD: A case-control study was undertaken detecting the polymorphism of apoE by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). RESULTS:(1) The frequencies of ?3/4 genotype and ?4 allele in AD were significantly higher than that in age-matched controls( P
