Effects of desmopressin acetate on hemostatic function and postoperative blood loss after cardiac surgery with cardiopulmonary bypass
- VernacularTitle:去氨加压素对体外循环术后病人减少出血量的观察
- Author:
Xiangyou YU
;
Jifeng YIN
;
Jun QIAO
- Publication Type:Journal Article
- Keywords:
Desmopressin;
Cardiopulmonary bypass;
Platelet;
von Willebrand factor;
Factor Ⅳ
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of desmopressin acetate (DDAVP) on blood loss and hemostatic function after cardiac surgery with extracorpoteal circulation.Methods Forty-one patients undergoing congenital heart operations, were randomly allocated to double--blindly receiving 0.3ug/kg DDAVP in a 50 ml saline(group DDAVP, n = 20) and 50ml normal saline (group placebo, n = 21) over 15 min after protamine infusion. Blood samples were obtained before operation, immediately before studied drug administration and 1 h after the administration, to measure the hematocrit, platelet count and aggregation, Factor Ⅷ coagulant activity and von Willebrand factor (vWF) concentration. Results The first postoperative 24-hour blood loss was significantly lower in group DDAVP than in group placebo [ (178 ? 90) ml vs (291 ? 98 ) ml, P 0 .05); The plasma level of vWF and factor Ⅷ coagulant activity markedly increased 1h after DDAVP administration as compared with those in group placebo, before operation and after protamine infusion in group DDAVP (P
