Comparison of effects of Dan Shen Extract F and cimetidine on reperfusion injury in gastric antrum
- VernacularTitle:丹参提取物F与西咪替丁抗胃窦部粘膜再灌注损伤作用的比较
- Author:
Lihong ZHANG
;
Jin ZHANG
;
Changbai YAO
- Publication Type:Journal Article
- Keywords:
Shock, hemorrhagic;
Reperfusion injury;
Gstric mucosa;
Salvia Miltiorrhiza;
Cimetidin
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of Dan Shen Extract F(DSEF) and cimetidine (CI) on reperfusion injury in gastric antrum. Methods Nineteen Wistar rats were randomly allocated to receiving intravenously normal saline (group NS, n = 7), DSEF 1g/100g wt (group DSEF, n = 6) or CI 6.5mg/ 100g wt (group CI, n = 6 ) respectively. Model of hemorrhagic shock roperfusion injury was produced by Itch method. The index and depth of gastric mucosal lesion, prostaglandins content and intracellular calcium content of gastric antrum mucosa were measured. Results (1 ) As compared with those in group NS, the index and depth of gastric mucosal lesion (grade 2, 3) decreased significantly in group DSEF and CI (P 0.05 ). (3 ) The intracellular calcium content in group DSEF and CI was markedly lower than that in group NS (P 0. 05). Conclusions Both DSEF and CI can prevent largely the reperfusion injury in gastric antrum mucosa through different mechanisms, with DSEF having stronger potency.
