Effects of propofol on macrescopic sodium currents in rat sympathetic neurons
- VernacularTitle:异丙酚对交感神经元钠通道电流的影响
- Author:
Jijian ZHENG
;
Xinliang ZHUANG
;
Baogang LIU
- Publication Type:Journal Article
- Keywords:
Propofol;
Ganglia, sympathetic;
Sodium channels
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of propofol on the whole-cell sodium currents in rat sympathetic neurons in order to investigate the mechanisms of propofol-mediated peripheral vasodilation.Methods Whole-cell patch-clamp recordings were made from enzymatically isolated rat superior cervical sympathetic neurons.Results Propofol dose-dependently blocked the whole-cell sodium currents evoked by a voltage step from a holding potential of -- 80mV to 0mV with a mean IC50 value of 32. 19?mol/L (r = 0. 982, P
