The renal L-arginine/nitric oxide pathway and erythrocyte L-arginine transport in spontaneously hypertensive rats
- VernacularTitle:自发性高血压大鼠肾脏L-精氨酸/一氧化氮系统与红细胞L-精氨酸转运
- Author:
Huizhen ZHENG
;
Xiaohong WANG
;
Chaoshu TANG
;
Xiy LIU
- Publication Type:Journal Article
- Keywords:
Arginine;
Nitric oxide;
Kidney;
Erythrocytes;
Hypertension
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the changes of the renal L-arginine /nitric oxide pathway and the relationship of L-arginine transport between kidney and erythrocytes in spontaneously hypertensive rat (SHR). METHODS: Sixteen week old SHR, 16 week old SHR with captopril (CAP) treated for four weeks and 16 week old WKY rats were used in the experiment. L-arginine transport, NO synthase(NOS) activity, nitrite and cyclic GMP (cGMP) content were measured in renal tissue or erythrocytes. RESULTS: In the renal tissue, compared with that of WKY group, the Vmax of high-or low-affinity L-arginine transporter, NOS activity, NO - 2 and cGMP content of SHR group were significantly decreased ( P
