Bone formation of alveolar augmentation with hydroxylapatite, bone morphogenetic protein and fibrin sealant composite
- VernacularTitle:羟基磷灰石+骨形成蛋白+纤维蛋白粘合剂复合物增高牙槽嵴的新骨形成反应
- Author:
Songling CHEN
;
Dazhang WANG
- Publication Type:Journal Article
- Keywords:
Bone and bones;
Fibrin tissue adhesive;
Alveolar ridge augmentation
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate new bone formation of alveolar augmentation with hydroxylapatite(HA)+bone morphogenetic protein(BMP)+fibrin sealant FS(HA+BMP+FS) composite.METHODS:Bone morphogenetic protein was extracted from bovine cortical bone. Hydroxylapatite particles were combined with fibrin sealant and BMP, which is of high efficient osteoinduction, forming a new complex material. The alveolar augmentation was made with this composite. The samples were investigated 3, 6,12 and 24 weeks postoperatively, with gross observation, microscope, calculation of new bone formation, tetracycline fluorescent microscope, scanning electron microscope, backscattered electron image and X-ray energy analysis.RESULTS: 1. In experimental group, weave bone had been seen since 3 weeks postoperatively and more new bone 6 weeks postoperatively; remolded bones united and distributed to all spaces of HA particles 12～24 weeks postoperatively. In control group, no new bone appeared 3 weeks postoperatively, only some HA particles contacted base bone 6 weeks postoperatively, a little of new bone grew into HA spaces 12～24 weeks postoperatively. 2. New bone directly incorporated with HA. The quantity of calcium and phosphate are similar to HA and base bone. CONCLUSION:This composite in alveolar augmentation obviously promotes incorporation HA with base bone, speeds formation of new bone and adds amount of new bone, reconstructing a bony alveolar ridge.
