Progress in the study on establishment and characteristics of viral L6565 cell clone
- VernacularTitle:病毒性L6565白血病细胞克隆株的建立及其特性研究进展
- Author:
Li CHENG
;
Lianhua YIN
;
Xinyong ZHAO
- Publication Type:Journal Article
- Keywords:
Leukemia;
Clone cells;
Oncogenes
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
A Review] The biological characteristics of viral L6565 leukemia cell clone were as follows: (1) The chromosome counts varied 38～114 , and stem cells were 42; (2) Virus particles type A and type C found in the cytoplasm of clone cells; (3) X-C assays were positive, c- myc and c- fos gene overexpressed in clone cells; (4) Differential markers CD4, CD8, CD45R were negative, CD45RO ? were positive; (5) The supernatant of clone cells could induce T or B lymphocytic leukemia/lymphoma and granulocytic leukemia in SSB strain mice. The leukemogenic effect of concentrate supernatant was stronger than non-concentrate supernatant( P
