Clinical study on injury and activation of the vascular endothelial cells during cardiopulmonary bypass
- VernacularTitle:体外循环对血管内皮细胞损伤/活化的临床研究
- Author:
Liyong CHEN
;
Hengjiang GE
;
Huaiqiong LIU
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Circulating endothelial cell;
Thrombomodulin;
von Willebrand factor
- From:
Chinese Journal of Anesthesiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study vascular endothelial cell injury/activation associated with CPB in order to understand the pathophysiology of the complications of patients undergoing cardiovascular operationsMethods Twenty-six patients scheduled for cardiac operations with CPB, were divided into two grourps, group Ⅰ: 14 patients with acyanotic congenital heart diseases undergoing corrective surgical procedures; group Ⅱ: 12 patients undergoing selective cardiac operation for valvular replacement Blood samples were withdrawn from central vein before skin incision,before CPB, 30 min following CPB, at end of CPB, at end of operation, on the first postoperative day and the third postoperative day to measure the levels of circulating endothelial cells(CEC), thrombomodulin(TM) and von Willebrand Factor(vWF).Results The levels of CEC,TM and vWF significantly elevated during CPB and on the first postoperative day in the two groups,as compared with those before operation (P
