Endogenous basic fibroblst growth factor is a protective factor against myocardial ischemia/reperfusion injury of rats
- VernacularTitle:内源性碱性成纤维细胞生长因子是大鼠对抗心脏缺血/再灌注损伤的保护因子
- Author:
Zhisheng JIANG
;
Xiaohong WANG
;
Shulian LI
;
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor,basic;
Heart;
Reperfusion injury;
Signal transduction;
Rats
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the role of exogenous and endogenous basic fibroblst growth factor (bFGF) on myocardial ischemia/reperfusion(I/R) injury of rats.METHODS:bFGF and bFGF antiserum were applied to rat isolated I/R heart. Myocardial function, coronary effluent volume,protein and myoglobin content as well as LDH activity in coronary effluent fluid, myocardial calcium, MDA and ATP concentration as well as PKC, MAPK activity were measured. RESULTS:Compared with control, myocardial function in I/R group significantly decreased. Protein, myoglobin content and LDH activity in coronary effluent liquid as well as myocardial MDA and calcium content increased, while myocardial ATP concentration decreased(all P
