The influence of oral simvastatin and vitamine-E on serum LDL oxidation and platelet activation in coronary artery disease patients
- VernacularTitle:辛伐他汀、维生素E联用对冠心病患者氧化修饰低密度脂蛋白及血小板活化的影响
- Author:
Zhiming YANG
;
Yuzhen GAO
;
Chuanshi XIAO
;
Yunfei BIAN
;
Shufen LIANG
;
Fengzi WANG
- Publication Type:Journal Article
- Keywords:
Vitamin E;
Lipoproteins;
Coronary disease;
Blood platelets
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: Using simvastatin and vitamine E (Vit-E) treatment to coronary artery disease (CAD) patients with low HDL, to investigate the relationship between Ox-LDL, platelet activation and HDL. METHODS: 40 CAD patients with low HDL were divided into two groups (A and B): A group oral simvastatin, B group oral simvastatin and Vit-E. The level of serum Ox-LDL, TXB 2 and GMP-140 were measured before and after treatment. The relationship between Ox-LDL, TXB 2, GMP-140 and HDL were analysed. RESULTS:The level of serum HDL was significantly increased in A and B group after treatment and attained normal level. The level of serum Ox-LDL, TXB 2 and GMP-140 were decreased significantly after simvastatin and Vit-E treatment and neared normal. CONCLUSIONS:This study confirmed that HDL can effectively refrain LDL oxidation. It also revealed that Vit-E and simvastatin treatment were more effectively refrained platelet activation by increasement of HDL and decreasement of Ox-LDL.
