Synergetic antagonism of polymyxin B associated with glycine to pyrogenous effect of endotoxin
- VernacularTitle:甘氨酸与多粘菌素B联用拮抗内毒素致热性及降多粘菌素B毒性的研究
- Author:
Wei LU
;
Daxiang LU
;
Yanping WANG
;
Chuji LI
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Glycine;
Polymyxin B
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: To investigate the antagonistic effects of polymyxin B(PMB) in combination with glycine(Gly) on the pyrogenicity of endotoxin(ET) in rabbits and the LD 50 of PMB in mice. RESULTS: (1)The antagonistic effect of PMB plus Gly was augmented and the optimal combination was PMB(30 000 U) plus Gly(15 mg) to ET(0.01 ?g); (2)The LD 50 of PMB with or without Gly were 8.38?10 4 U/kg and 6.06?10 4 U/kg in mice, respectively. CONCLUSION: The antagonistic effect of PMB plus Gly on ET showed synergnism and this combination could decrease the toxicity of PMB.
