Effects of glucose and Mg~(2+) in the neurons damaged by glutamate
- VernacularTitle:葡萄糖和镁离子在谷氨酸诱发的神经细胞损伤中的作用
- Author:
Hong XING
;
Qihua HE
;
Lan YUAN
;
Jialing XU
;
Benji WU
- Publication Type:Journal Article
- Keywords:
Glutamates;
Glucose;
Magnesium;
Calcium
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: To observe the effects of glucose-free and Mg 2+ -free in the extracellular fluid on the changes of [Ca 2+ ] i in the cerebro-cortical neurons damaged by 1 mmol/L glutamate using laser confocal scanning microscope. RESULTS: Both frequency and amplitude of neuronal calcium oscillation induced by glutamate were lowered in glucose-free and Mg 2+ -free buffers. The basic [Ca 2+ ] i concentration was lowered in the former case , but it was elevated in the latter case. CONCLUSION: Mg 2+ -free aggravates [Ca 2+ ] i overload induced by 1 mmol/L glutamate ,under certain conditions the glucose-free might resist damage role of glutamate and Mg 2+ -free.
