Effect of trichosanthes injection on expression of proliferating cell nuclear antigen of vascular smooth muscle cell in rabbit
- VernacularTitle:瓜蒌注射液对兔血管平滑肌细胞增殖细胞核抗原表达的影响
- Author:
Zicheng LI
;
Qing CHANG
- Publication Type:Journal Article
- Keywords:
Thichosanthes;
Drugs, Chinese herbal;
Muscle, smooth, vascular;
Cells;
Antigens
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of thichosanthes injection on the expression of proliferating cell nuclear antigen (PCNA) of vascular smooth muscle cell (SMC). METHODS: The expression of PCNA of cultured rabbit aortic SMC was examined with LSAB immunohistochemical technique, and [ 3H]-thymidine([ 3H]-TdR) incorporation data of SMC and the contents of superoxide dismutase (SOD), lipid peroxide (LPO), prostacyclin (PGI 2) and cyclic AMP (cAMP) in medium were simultaneously determined. RESULTS: Thichosanthes injection has an effects of increasing SOD activity, decreasing LPO, elevating PGI 2 and cAMP, reducing [ 3H]-TdR incorporation and expression of PCNA (all P
