Influence of APP17 peptide on the study ability, memory and NT-3, NGF expression of the hippocampus neurons D-galactose induced brain aging model mice
- VernacularTitle:APP17肽对D-半乳糖性脑老化模型小鼠学习、记忆功能和海马神经元NT-3、NGF表达的影响
- Author:
Jing WANG
;
Zhijuan JI
;
Zhiwei ZHAO
;
Yongmei ZHAO
;
Shuli SHENG
- Publication Type:Journal Article
- Keywords:
Peptides;
D-Galactose;
Disease model, animal;
Nerve growth factors
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the influence of beta-amyloid precursor protein (APP17) on the study ability, memory and the expression of neurotrophin-3 (NT-3), nerve growth factor(NGF)in the hippocampus neuron of the model mice. METHODS: Mice brain aging model were produced with D-galactose(D-gal), the model mice were given hypodermic injection of APP17 peptide. APP17 peptide is the 319-335 peptide sequence of beta-amyloid precursor protein. Eight weeks later, the animals were observed by water labyrinth test and immunohistochemistry assay. RESULT:(1) The whole time needed and total times of wrong response for the D-gal group mice to complete the whole course of the water labyrinth test is significantly higher than the normal control group. (2) The expression of NT-3, NGF in the hippocampus neurons of the mice in APP17 peptide group is significantly higher than that of the normal control group and D-gal mice group, P
