The effect of EBV latent membrane protein 1 on proliferation and cell cycle of nasopharyngeal carcinoma cells
- VernacularTitle:EB病毒LMP1表达对鼻咽癌细胞增殖及细胞周期分布的影响
- Author:
Peichun HUANG
;
Hongying LIANG
;
Huihua DENG
;
Kangrong CAI
;
Minglun ZHAO
- Publication Type:Journal Article
- Keywords:
Epstein-Barr virus;
Nasopharyngeal neoplasms;
Cell line;
Cell division;
Cell cycle
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of Epstain-Barr virus latent membrane protein 1 (EBV-LMP1) on proliferation and cell cycle of nasopharyngeal carcinoma (NPC) cells. METHODS:The expression of EBV-LMP1 was detected by immunohistochemical method (LSAB). Proliferation of NPC cells was identified by MTT method. Cell cycle percentage was detected by flow cytometry analysis. RESULTS: OD value of EBV-LMP1 expressive NPC cells L-CEN1 was much higher than that of both EBV-LMP1 negative NPC cells V-CEN1 and CNE1 ( P 0.05).CONCLUSION:The expression of EBV-LMP1 on NPC cell might cause some change of cell cycle and enhance cell proliferation.
