Application of cardiac troponin I to the diagnosis of myocardial injury following CPB
- VernacularTitle:心肌肌钙蛋白Ⅰ对体外循环期心肌损伤的判定价值
- Author:
Ping WANG
;
Xiusheng FANG
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Myocardium;
Troponin I;
Myocardial reperfusion injury;
Diagnosis
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of cardiac troponin I(cTnI) in the diagnosis of myocardial ischemic injury.Methods Twenty patients were randomly divided into two groups: group I (cold crystalloid cardioplegia, n=10) and group Ⅱ (cold blood cardioplegia, n=10). The central venous blood samples were taken at various times during perioperation to measure the serum levels of cTnI,CK MB and CK . Myocardial samples were obtained 10 min before aorta clamping and 30 min after aotra unclamping, to observe myocardial ultrastructure .Results cTnI,CK and CK MB levels were normal before operation, increased markablely following aotra unclamping ,reached the peak 1 h after aorta unclamping to 24 h after operation, and decreased progressively to be normal in two groups. The serum cTnI level was significantly lower in group Ⅱ than that in group Ⅰ 24 h and 48 h after operation. The serum CK MB activity was lower in group Ⅱ than that in group Ⅰ 1 h after aorta unclamping. There was positive significant correlation between aorta cross clamping time and cTnI peak level.Conclusions cTnI can be used to evaluate the degree of myocardial injury and myocardial protective effect in open heart surgery during CPB. As indicators for reflecting the myocardial injury, the sensitivity and specificity of cTnI are more valuable than those of myocardial enzymes.
