Effect of desflurane on serum and urine fluoride and renal function in patients during general anesthesia
- VernacularTitle:地氟醚对全麻病人血氟、尿氟及肾功能的影响
- Author:
Jie HU
;
Junke WANG
;
Zhiguo YUAN
- Publication Type:Journal Article
- Keywords:
Pharmacodynamics;
Desflurane;
Fluoride ion;
Renal function
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of serum and urine fluoride,Cr and BUN in patients with desflurane inhalation.Methods Twenty patients ASA class I, scheduled for selective surgery, were selected. The anesthesia was induced with fentanyl, propofol and vecuronium and was maintained with inhaling desflurane. Arterial and venous blood samples were drawn before desflurane inhalation, at the end of operation, 4 h, 24 h, 72 h and 144 h after operation. Urine were collected at the same time. Serum and urine fluoride levels were detected with fluoride ion electrode methods.Results Inhalation of desflurane was maintained for (4.36?0.39)h at concentration of (1.65?0.16)MAC, with the total inhalation amount of MAC (7.19?0.82)MAC h. No significant changes occurred in either serum fluoride concentration or urine fluoride excretion rate. Cr and BUN contents showed unsignificant changes during whole procedures.Conclusions Desflurane inhalation has no effect on serum and urine fluoride concentrations and renal function.
