Effect of Hyperoxia on Neonatal Rat Lung
- VernacularTitle:高浓度氧对新生鼠肺的影响
- Author:
Zhiting WAN
;
Liwen CHANG
;
Ye CHEN
- Publication Type:Journal Article
- Keywords:
Rats;
Oxygen;
Pulmonary fibrosis
- From:
Chinese Journal of Perinatal Medicine
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of prolonged hyperoxia on neonatal rat lung. Methods Full term and premature newborn SD rats were continuosly exposed to 85% oxygen or room air 7 and 14 days after birth.The activities of 3 different kinds of antioxidant enzyme (AOE) including superoxide dismutase(SOD), glutathion peroxidase (GP) and catalase (CAT) in supernatant fractions of lung homogenates were assessed after 7 and 14 days of exposure. So was the lung hydroproline content. Results (1)AOE acctivitis: Except CAT activity at 14 days of exposure, others AOE activities in O 2 exposed rat pups were significantly higher than those in air exposed controls (P
