Inducible nitric oxide synthase and arterial pressure regulation
- VernacularTitle:诱导型一氧化氮合酶与动脉血压的调节
- Author:
Shaobing CHENG
;
Dunyong TAN
;
Xiaolin CHEN
;
Haozhuang YANG
;
Suimei ZHANG
;
Liang YAN
- Publication Type:Journal Article
- Keywords:
Nitric oxide;
Blood pressure;
Rats;
Sodium chloride
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and MEfTHODS: To clarify the role of inducible nitric oxide synthase (iNOS) in the regula- tion of blood pressure, in the present study, we examined the effect of aminoguanidine (AG), a selective inhibitor of iNOS on the hemodinamical response of Dahl salt - sensitive (DS) and Dahl salt - resistant (DR) rats to low (0. 3% ) or high (8%) sodium chloride (Nacl) infusion by chronical in vivo hemodynamic experiment, and the effect of NaCl or NaCl plus AG infusion on urinary nitrate (NO3)/nitrite (NO2), the end product of nitric oxide (NO),ex- cretion by Greiss Reaction. Furthermore, NOS activity assay was the dried out to probe the effect of NaCl and AG on calcium - dependent or independent NOS activity in renal tissue. RESULTS:1. High or low NaCl - infused DR rats and low NaCl - infused DS rats have no hemodinamical response to AG, however, the hpertensive effect of high NaCl (8% ) infusion on DS rats were gnatly amplified by co - infusion of AG. 2. Administration of high NaCl signif- icantly elevated the iNOS activity of renal tissue, and greatly increased urinary NO3/NO2 excretion. CONCLUSION: Ihducthle NOS is an important modulator of arterial pressure, especially in case of higher blood pressure.
