Role of angiotensin Ⅱ on type Ⅰcollagen synthesis and its mRNA expression in vascular adventitial fibroblasts
- VernacularTitle:血管紧张素Ⅱ对血管外膜成纤维细胞Ⅰ型胶原合成及其mRNA表达的影响
- Author:
Ting TAO
;
Dingliang ZHU
;
Lansheng GONG
- Publication Type:Journal Article
- Keywords:
Angiotensin Ⅱ;
Blood vessels;
Fibroblasts;
Collagen
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:Effects of anatotensin Ⅱ on type Ⅰ collagen synthesis and its mRNA expansion in cultured vascular adventitial fibroblasts. METHODS: Vascular adventitial fibroblasts (VAF)were isolated, cultured from rat thoracic aorta by explant method. ELISA was used to study type Ⅰ collagen synthesis and competihve RT - PCR was employed to detect its mRNA expression after angiotensin Ⅱ administration. RESULTS: Angiontensin Ⅱ caused a dose dependent increase of type Ⅰ collagen synthesis and its mRN expression in VAF. CONCLUSION: The results support that angiotensin Ⅱ is an important factor controlling collagen metabolism of VAF and VAF may play an im- portant role in vascular remodelling of hypertension.
