Effect of thrombopoietin on platelet activation in vitro
- VernacularTitle:血小板生成素对体外人血小板活化的影响
- Author:
Xin DU
;
Mingchun WANG
;
Ming LI
;
Junmei WAN
- Publication Type:Journal Article
- Keywords:
Thrombopoietin;
Platelet activation;
Fluorescent antibody technique;
Flow cytometry
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effects of thrombopoietin (TPO) and other hematopoietic cytokines on platelet activation. METHODS: Using fluorescent-labeled monoclonal antibodies and flow cytometry.RESULTS: The per- centage range of platelets activated by 120 ng/mL TPO was 8. 89% -39. 92%,mean value was 17.43%; However, there were no effects of TPO 40 ng/mL and GM - CSF 100 ng/mL and IL- 3 100 ng/mL on platelet activation. CONCLUSION: Higher concentration of TPO directly stimulated platelet activation.
