The effect of anti-digoxin antiserum on endoxin and membrane ATPase activity in hypoxic myocardium
- VernacularTitle:地高辛抗血清对缺氧损伤心肌组织内洋地黄素和心肌细胞膜ATP酶活性的影响
- Author:
Zhaofang LIU
;
Yongsheng KE
;
Guanghua CHENG
;
Youxia WANG
- Publication Type:Journal Article
- Keywords:
Myocardium;
Anoxia;
Digitalis;
Adenosine triphosphatase, sodium,potassium;
Digoxin
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the antagonistic effect of anti - digoxin antiserum on hypoxic myocardium and its mechanism. METHODS: It was observed that different concentration of anti-digoxin antiserum effect on endoxin and cell membrane ATPase activity in hypoxic myocardium model. RESULTS: The endoxin level was much higher, cell membrane ATPase activity was much lower in hypoxic myocedium than those of noed; anti-digoxin antiserum can resume membrane ATPase activity. CONCLUSION: Rise of endoxin was basic in molecular biology of myocar- dial damage during myocardial hypoxia. Anti - digoxin antiserum decreased myocardial damge and has protective ef- fect on hypoxic myocardium by antagonistic effeCt of endoxin.
