Relativity of beta adrenoceoptor changes between polymorphonuclear leukocytes and lung tissue in acute lung injury rats
- VernacularTitle:急性肺损伤大鼠多核白细胞与肺组织?受体变化的相关性研究
- Author:
Xingxiang XU
;
Gengyun SUN
;
Guisheng QIAN
;
Jieju DONG
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Lung;
Wounds and injuries;
Receptors, adrenergic, beta;
Neutrophils;
Rats
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe changes of beta - adrenoceptor (?-AR) and its relativity to polymorphonulear leukocytes (PMN) and acute lung injury (ALI) in rats. METHODS: ALI modle in rat was established by in- travonous injection of E. Coli endotoxin (ET). ? - AR was measured by radioligand binding assay with [3H]-dihy- droalprenlol. RESULTS: (1)Maxmal capacity of ? - AR (Bmax) in both lung tissue and PMN decreased significantly at the lst, 4th and 6th hours after injection of or. (2)No relativity was found between ?-AR Bmax changes of lung tissue and ?-AR Bmax changes of PMN. CONCLUSIONS: (1) Decrease of density of 3-AR in lung tissue and PMN may played a role in the development of ALI. (2) The ?-AN of PMN in circular bind can not be used as a relative index of ?-AR changes of lung tissue in rats with ALI.
