Effect of ligustrazine on pulmonary arterial pressure and pulmonary arterial wall collagen of chronic hypoxic hypercapnic rats
- VernacularTitle:川芎嗪对慢性低氧高二氧化碳大鼠肺动脉压力及管壁胶原的影响
- Author:
Zhijie GAO
;
Liangxing WANG
;
Qunji WANG
;
Yupeng XIE
;
Yanfan CHEN
;
Shaoxian CHEN
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Drugs, Chinese herbal;
Anoxia;
Hypercapnia;
Hypertension, pulmonary;
Collagen
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of ligustrazine on pulmonary hypertensive rats induced by hypoxic hy- percapnia. METHODS: Thirty rats were randomly divided into three groups: control group(A), hypoxic hypercapnic group (B), hypoxic hypercapnia+ligustrazine (lig. ) group(C). RESULTS: (1) Mean pulmonary axterial pressure (mPAP)of group B was significantly higher than that of group A and mPAP of group C was significantly lower than that of group B(P0.05); (2)Electron microscopy and immunohistochemistry showed ligustrazing could inhibit the diposition of col- lagenous fiber(collagen type Ⅰ )in pulmonary arterioles induced by hypoxic hypercapnia; (3) Plasma endothelin level of group C was significantly lower than that of group B (P
