Urinary Sodium Excretion Has Positive Correlation with Activation of Urinary Renin Angiotensin System and Reactive Oxygen Species in Hypertensive Chronic Kidney Disease.
10.3346/jkms.2014.29.S2.S123
- Author:
Shin Young AHN
1
;
Sejoong KIM
;
Dong Ki KIM
;
Jung Hwan PARK
;
Sung Joon SHIN
;
Sang Ho LEE
;
Bum Soon CHOI
;
Chun Soo LIM
;
Suhnggwon KIM
;
Ho Jun CHIN
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. mednep@snubh.org
- Publication Type:Original Article
- Keywords:
Chronic Renal Insufficiency;
Sodium Chloride;
Renin;
Angiotensinogen
- MeSH:
Adult;
Aged;
Angiotensinogen/urine;
Chemokine CCL2/urine;
Creatine/urine;
Demography;
Female;
Follow-Up Studies;
Humans;
Hypertension/complications;
Male;
Malondialdehyde/urine;
Middle Aged;
Reactive Oxygen Species/*metabolism;
Renal Insufficiency, Chronic/complications/*pathology;
Renin-Angiotensin System/*physiology;
Sodium, Dietary/*urine;
Urine Specimen Collection
- From:Journal of Korean Medical Science
2014;29(Suppl 2):S123-S130
- CountryRepublic of Korea
- Language:English
-
Abstract:
It is not well described the pathophysiology of renal injuries caused by a high salt intake in humans. The authors analyzed the relationship between the 24-hr urine sodium-to-creatinine ratio (24HUna/cr) and renal injury parameters such as urine angiotensinogen (uAGT/cr), monocyte chemoattractant peptide-1 (uMCP1/cr), and malondialdehyde-to-creatinine ratio (uMDA/cr) by using the data derived from 226 hypertensive chronic kidney disease patients. At baseline, the 24HUna/cr group or levels had a positive correlation with uAGT/cr and uMDA/cr adjusted for related factors (P<0.001 for each analysis). When we estimated uAGT/cr in the 24HUna/cr groups by ANCOVA, the uAGT/cr in patients with > or =200 mEq/g cr was higher than in patients with <100 mEq/g cr (708 [95% CI, 448-967] vs. 334 [95% CI, 184-483] pg/mg cr, P=0.014). Similarly, uMDA/cr was estimated as 0.17 (95% CI, 0.14-0.21) pM/mg cr in patients with <100 mEq/g cr and 0.27 (95% CI, 0.20-0.33) pM/mg cr in patients with > or =200 mEq/g cr (P=0.016). During the 16-week follow-up period, an increase in urinary sodium excretion predicted an increase in urinary angiotensinogen excretion. In conclusion, high salt intake increases renal renin-angiotensin-system (RAS) activation, primarily, and directly or indirectly affects the production of reactive oxygen species through renal RAS activation.
