Effect of membrane environment at high temperature on voltage-dependence of delayed rectifier K~（+） channel in hypothalamus neurons
- VernacularTitle:膜环境高温对下丘脑神经元膜上钾通道电压依赖性的影响
- Author:
Chunqing CAI
;
Fei ZOU
;
Shoucheng ZHU
- Publication Type:Journal Article
- Keywords:
Temprature;
Potassium channels;
Hypothalamus;
Neurons
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effects of high temperature on voltage - dependence of delayed rectifier K+ channel (Ik) in hypothalamus neurons. METHODS: The date recording from cell - attached patches of patch - clamp technique. RESULTS: With temperature raising, shift of voltage dependence may be mediated at different degree, while higher temperature might weaken and depressed. CONCLUSION: Shift of voltage dependence likely contribut- ed to the body fever and heatstroke.
