Inhibitory effects of Ginkgolide A on stress ulceration in rats
- VernacularTitle:银杏内酯A对应激性溃疡发生的抑制作用
- Author:
Genbao ZHANG
;
Daqing QIAN
;
Jun SUN
- Publication Type:Journal Article
- Keywords:
Ginkgolides/Pharmacology;
Stress;
Free ladleals;
Muscles;
Electrophysiology;
Ulcer
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protective effects and its mechanism of Ginkoglide A on stress ulceration in fats. METHODS: Wistar rats were randomly assigned to control, and Ginkgolides pretreatment group. The stress ulceration was produced by water immersion restraint, and gastric myoelectric activity during during was recorded by implanting electrodes in the stomach antrum smooth muscle. The malondialdehyde (MDA) concentration and superox- ide dismutase (SOD) activity in plasma, and gastric mucusal lesions were examined after the rat was killed. RE- SULT: Compared with the control group, previous intraperitoneal administratin of Ginkgolide A (5 - 20 mg/kg) not only had a highly significant decrease on stress - induced myoelectric activity disorder (P
