Effects of peroxynitrite on the endothelial cells
- VernacularTitle:过氧亚硝酸盐在内皮细胞损伤中的作用
- Author:
Yu CHEN
;
Huiming JIN
- Publication Type:Journal Article
- Keywords:
Nitrites;
Endothelium;
Cells;
Nitric oxide
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
A Review] Endothelial cells produce both superoxide and nitric oxide. Nitric oxide and superox- ide are known to react rapidly to form the stable peroxynitrite anion. Peroxynitrite mediates the oxidation of protein, lipid, deoxyribose and inhibits mitochondrial electron transport. Peroxynitrite may break DNA strands and activate poly(ADP - ribose) syntheatase. If the reaction is excessive, it results in a depletion of intracelular NAD+ and ATP. There is ultimately cell death.
